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Allopurinol Side Effects Forum Status

This is a new forum where I'm currently organizing unresolved concerns from old gout forum posts. Next, I'll start researching new templates that will help you resolve your concerns about side effects of allopurinol.

Allopurinol Side Effects Forum Topics

You can add your questions, experiences, or opinions in the comments below about any aspect of allopurinol side effects. In the meantime, here are some topics from my earlier gout forums:

Do antibiotics increase allopurinol side effects?

In Allopurinol side effects and cloxacillin, Gibe asked:

Just want to ask if I can still continue to take 300 mg allopurinol.
I used to take it for about 3 weeks. But when I take it together with cloxacillin I noticed some feelings of shortness of breath. Also, some itchy red spot. But when I stop taking both of them, the side effects suddenly stops.

So I've started researching antibiotics and allopurinol. Finding the following:

Batista, M., Cardoso, J.C., Oliveira, P. and Gonçalo, M., 2018. Allopurinol-induced DRESS syndrome presented as a cholecystitis-like acute abdomen and aggravated by antibiotics. Case Reports, 2018, pp.bcr-2018.

This case study considers Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome. Especially where the syndrome is promoted by antibiotics affecting allopurinol.

Antibiotics may aggravate DRESS by enhancing HHV6 proliferation within infected lymphomononuclear cells in target organs5 or by a co-sensitisation phenomenon.
Antibiotic-induced exanthema occurs more frequently in conditions with previous immune activation, like in infectious mononucleosis, and a percentage of these patients become permanently sensitised to the drug. This may also occur in DRESS where, apart from the culprit drug, we find frequent positive patch tests to antibiotics that are maintained in time.6 This seems to be the case for our patient as well, who used two different antibiotics and presented with an exanthema 2 days after surgery. [https://doi.org/10.1136%2Fbcr-2018-226023]

Syu, F.K., Pan, H.Y., Chuang, P.C., Huang, Y.S., Cheng, C.Y. and Cheng, F.J., 2018. Incidence of Stevens–Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: a case–control study. The Journal of Dermatology, 45(9), pp.1080-1087.

This case-controlled study investigates the incidence of Stevens–Johnson syndrome (SJS), the frequency of SJS diagnosis, and the association between SJS and prior use of allopurinol, carbamazepine or phenytoin.

phenobarbital, valproate, non-steroidal anti-inflammatory drugs (NSAIDs) including piroxicam and tenoxicam, and antibiotics including amoxicillin and cephalexin were strongly associated with SJS. Patients with gout or epilepsy taking allopurinol, carbamazepine or phenytoin should be evaluated carefully by physicians. [https://onlinelibrary.wiley.com/doi/abs/10.1111/1346-8138.14528]

What's your allopurinol side effects story?

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